Andrographis paniculata is well known plant by the name ‘kalamegha’ Kalamegha, meaning is "dark cloud" because of its appearance from a distance like a black cloud in the blue sky. It is also known as Bhui-neem, meaning "neem of the ground,Andrographis and Kirayat.It is an Ayurvedic herb, used for the treatment of diseases of Kushta (skin diseases), Kandu (itching), Shopha(swelling), Yakrutroga (liver diseases), Krimi(worms), Jwara (fever). This is widely cultivated in Southern Asia, is a herbaceous plant, commonly known as “King of Bitters” belonging to the family of Acanthaceae. A. paniculata is an annual profusely branched, erect herb extremely bitter in taste. It grows to a height of 30-110 cm in moist shady places with glabrous leaves and white flowers with rose purple spots on the petal.The whole plant is used in medicinal purposes. Andrographolide, neoandrographolide, andrograpanin, 12-didehydroandrographolide, are the principal chemical constituen